Since my childhood I always found there is a clear gender bias in society. Initially I use to think it is only with the career opportunities clubbed with societal taboos; for example I have seen many girls to discontinue their career including higher studies and highly talented musicians after marriage. But later (when I grew up) I also realized that this discrepancies persists in biomedical research too where to study disease mechanisms people always prefer male animal models for simplicity. This outlook first time came to my mind during doctoral studies on reproductive biology when I felt male and female reproductive systems are so different and can not be compared. Later in my post doc I reoriented my field towards neurobiology then I understand that in brains are also having a distinct sex difference so to address CNS related diseases one can not generalized the findings irrespective of sexes and both sexes should be addressed individually to get insight into the disease mechanisms.